Shigeki Kushimoto Selected Research

Dacarbazine (DIC)

1/2022	Age-related differences in the survival benefit of the administration of antithrombin, recombinant human thrombomodulin, or their combination in sepsis.
1/2021	Pathophysiology of Coagulopathy Induced by Traumatic Brain Injury Is Identical to That of Disseminated Intravascular Coagulation With Hyperfibrinolysis.
1/2021	Disseminated intravascular coagulation immediately after trauma predicts a poor prognosis in severely injured patients.
1/2020	The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome.
1/2020	A multicenter prospective validation study on disseminated intravascular coagulation in trauma-induced coagulopathy.
11/2019	Identifying Sepsis Populations Benefitting from Anticoagulant Therapy: A Prospective Cohort Study Incorporating a Restricted Cubic Spline Regression Model.
9/2019	Significance of plasma fibrinogen level and antithrombin activity in sepsis: A multicenter cohort study using a cubic spline model.
7/2019	Diagnosis of sepsis-induced disseminated intravascular coagulation and coagulopathy.
6/2019	Role of disseminated intravascular coagulation in severe sepsis.
1/2019	Sepsis-associated disseminated intravascular coagulation and its differential diagnoses.

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Shigeki Kushimoto Research Topics

Disease

49	Sepsis (Septicemia) 01/2022 - 06/2005
29	Disseminated Intravascular Coagulation 01/2022 - 03/2006
20	Wounds and Injuries (Trauma) 04/2022 - 01/2007
14	Septic Shock (Toxic Shock Syndrome) 08/2021 - 06/2007
11	Infections 05/2022 - 09/2012
11	Hemorrhage 04/2022 - 01/2003
11	Thrombosis (Thrombus) 11/2019 - 03/2006
6	Out-of-Hospital Cardiac Arrest 11/2022 - 07/2012
6	Multiple Organ Failure (MODS) 01/2021 - 03/2009
6	Hypothermia 05/2020 - 11/2013
6	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2018 - 06/2007
6	Inflammation (Inflammations) 12/2016 - 06/2007
5	Poisoning 10/2017 - 07/2006
4	Thrombocytopenia (Thrombopenia) 01/2022 - 10/2007
4	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2021 - 01/2011
4	Communicable Diseases (Infectious Diseases) 08/2011 - 06/2005
3	Critical Illness (Critically Ill) 10/2016 - 06/2007
3	Burns 11/2014 - 08/2011
3	Bacterial Infections (Bacterial Infection) 02/2011 - 06/2005
3	Ischemia 01/2011 - 09/2002
3	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2008 - 06/2005
2	COVID-19 05/2022 - 01/2021
2	Heart Arrest (Cardiac Arrest) 04/2022 - 08/2015
2	Frailty 08/2021 - 01/2021
2	Heart Failure 01/2020 - 10/2017
2	Hypotension (Low Blood Pressure) 10/2017 - 01/2017
2	Peritonitis 10/2017 - 04/2015
2	Acidosis 01/2017 - 09/2016
2	Pneumonia (Pneumonitis) 12/2016 - 08/2011
2	Pulmonary Edema 01/2014 - 12/2012
2	Neoplasms (Cancer) 11/2012 - 08/2011
2	Hematoma 01/2011 - 01/2003
2	Craniocerebral Trauma (Head Injury) 09/2007 - 09/2002
1	Ventricular Fibrillation 11/2022
1	Coma (Comas) 01/2022
1	Hyperoxia 01/2022
1	Delirium 01/2022
1	Confusion (Bewilderment) 01/2022

Drug/Important Bio-Agent (IBA)

29	Dacarbazine (DIC)FDA LinkGeneric 01/2022 - 03/2006
7	ThrombomodulinIBA 01/2022 - 09/2002
7	Fibrinogen (Factor I)FDA Link 09/2019 - 01/2008
6	AnticoagulantsIBA 01/2022 - 01/2010
6	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 01/2011
6	Indicators and Reagents (Reagents)IBA 10/2016 - 06/2005
5	AntithrombinsIBA 01/2022 - 09/2004
5	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2011
4	Proteins (Proteins, Gene)FDA Link 05/2022 - 01/2017
4	Anti-Bacterial Agents (Antibiotics)IBA 03/2020 - 01/2016
4	C-Reactive ProteinIBA 01/2020 - 06/2005
4	Hemostatics (Antihemorrhagics)IBA 01/2017 - 11/2007
4	ProcalcitoninIBA 02/2011 - 06/2005
3	Oxygen (Dioxygen)IBA 01/2021 - 03/2013
3	fibrin fragment D (D-dimer)IBA 01/2021 - 09/2012
3	Thrombin FDA Link 01/2020 - 09/2004
3	Biomarkers (Surrogate Marker)IBA 09/2019 - 06/2005
3	FibrinIBA 09/2016 - 09/2012
3	Carbon MonoxideIBA 01/2016 - 07/2006
2	Messenger RNA (mRNA)IBA 05/2022 - 10/2017
2	Dexmedetomidine FDA Link 01/2022 - 01/2021
2	Hypnotics and Sedatives (Sedatives)IBA 01/2022 - 01/2021
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2017
2	Adrenal Cortex Hormones (Corticosteroids)IBA 01/2021 - 06/2007
2	formycin diphosphate (FDP)IBA 01/2021 - 08/2011
2	Polymyxin B (Aerosporin)FDA LinkGeneric 11/2020 - 01/2018
2	EndotoxinsIBA 11/2020 - 06/2005
2	Complement System Proteins (Complement)IBA 05/2020 - 11/2017
2	Blood Glucose (Blood Sugar)IBA 01/2020 - 01/2015
2	Vitamin K FDA Link 01/2018 - 12/2017
2	diethylene glycolIBA 10/2017 - 01/2017
2	Bisoprolol (Concor)FDA LinkGeneric 10/2017 - 11/2014
2	CreatinineIBA 12/2016 - 12/2013
2	Mitochondrial DNA (mtDNA)IBA 01/2016 - 12/2013
2	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2014 - 08/2011
2	fibrinmonomerIBA 09/2012 - 08/2011
2	Pyruvic Acid (Pyruvate)IBA 11/2011 - 01/2011
2	von Willebrand FactorIBA 09/2007 - 09/2002
1	COVID-19 VaccinesIBA 05/2022
1	Propofol (Diprivan)FDA LinkGeneric 01/2022
1	Heparin (Liquaemin)FDA LinkGeneric 01/2022
1	Midazolam (Versed)FDA LinkGeneric 01/2022
1	AntibodiesIBA 01/2022
1	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022
1	Platelet Factor 4IBA 01/2022

Therapy/Procedure

14	Therapeutics 01/2022 - 06/2007
14	Critical Care (Surgical Intensive Care) 09/2021 - 01/2008
10	Resuscitation 01/2021 - 07/2012
4	Laparotomy 04/2015 - 01/2003
3	Cardiopulmonary Resuscitation (CPR) 11/2022 - 01/2021
3	Mechanical Ventilators (Ventilator) 01/2022 - 01/2014
3	Artificial Respiration (Mechanical Ventilation) 01/2022 - 01/2021
3	Patient Care Bundles 01/2022 - 11/2019
2	Glycemic Control 10/2021 - 02/2014
2	Length of Stay 08/2021 - 01/2021
2	Hemoperfusion 11/2020 - 01/2018
2	Catheters 01/2016 - 08/2015
1	Extracorporeal Circulation 11/2022
1	Induced Hypothermia 11/2022
1	Endovascular Aneurysm Repair 04/2022
1	Thoracotomy 04/2022
1	Extracorporeal Membrane Oxygenation 01/2022